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The He Laboratory is primarily interested in understanding the molecular workings of Wnt/b-catenin signaling in normal development and human pathology. In the absence of a Wnt ligand, the Axin destruction complex phosphorylates b-catenin to be degraded, preventing b-catenin from reaching the nucleus. Canonical Wnt signaling is initiated by the binding of a Wnt protein to coreceptors Frizzled and Lrp5/6, which recruits the Axin destruction complex to the membrane and allows b-catenin to accumulate and enter the nucleus to alt... read more
Kirby Neurobiology Center, 3 Blackfan Circle F.M, Boston, MA, 02115, United States
Get directionsWeekday | Schedule | Status |
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Mon | 9:00 a.m. to 6:00 p.m. | |
Tue | 9:00 a.m. to 6:00 p.m. | |
Wed | 9:00 a.m. to 6:00 p.m. | |
Thu | 9:00 a.m. to 6:00 p.m. | |
Fri | 9:00 a.m. to 6:00 p.m. | |
Sat | Closed | |
Sun | Closed |
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